Linker for activation of T cells

LAT
Identifiers
Aliases	LAT, Lat, LAT1, pp36, linker for activation of T-cells, IMD52, linker for activation of T cells
External IDs	OMIM: 602354; MGI: 1342293; HomoloGene: 7811; GeneCards: LAT; OMA:LAT - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	28,990,784 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	125,968,742 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; blood; ; appendix; ; right coronary artery; ; spleen; ; popliteal artery; ; tibial arteries; ; monocyte; ; Descending thoracic aorta;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; blood; ; spleen; ; subcutaneous adipose tissue; ; Ileal epithelium; ; embryo; ; bone marrow; ; pharynx; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein kinase binding;
Cellular component	integral component of membrane; membrane; cell-cell junction; mast cell granule; immunological synapse; membrane raft; COP9 signalosome; Golgi apparatus; plasma membrane;
Biological process	intracellular signal transduction; adaptive immune response; gene expression; homeostasis of number of cells; regulation of T cell activation; immune system process; lymphocyte homeostasis; MAPK cascade; Fc-epsilon receptor signaling pathway; immune response; integrin-mediated signaling pathway; mast cell degranulation; inflammatory response; T cell receptor signaling pathway; T cell activation; calcium-mediated signaling; signal transduction; positive regulation of protein kinase activity; Ras protein signal transduction; positive regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	27040
	16797
	ENSG00000213658
	ENSMUSG00000030742
	O43561
	O54957
	NM_001014987; NM_001014988; NM_001014989; NM_014387
	NM_010689
	NP_001014987; NP_001014988; NP_001014989; NP_055202
	NP_034819
	Wikidata
View/Edit Human	View/Edit Mouse

The Linker for activation of T cells, also known as linker of activated T cells or LAT, is a protein involved in the T-cell antigen receptor signal transduction pathway which in humans is encoded by the LAT gene. Alternative splicing results in multiple transcript variants encoding different isoforms.