LAT2

LAT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MAZ
Identifiers
Aliases	LAT2, LAB, NTAL, WBSCR15, WBSCR5, WSCR5, HSPC046, linker for activation of T-cells family member 2, linker for activation of T cells family member 2
External IDs	OMIM: 605719; MGI: 1926479; HomoloGene: 11297; GeneCards: LAT2; OMA:LAT2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	74,229,834 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	134,643,879 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; bone marrow; ; spleen; ; appendix; ; bone marrow cells; ; lymph node; ; trabecular bone; ; superficial temporal artery;
	Top expressed in
	spleen; ; granulocyte; ; ankle joint; ; mesenteric lymph nodes; ; blood; ; spermatocyte; ; morula; ; lip; ; stroma of bone marrow; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; SH2 domain binding;
Cellular component	integral component of membrane; membrane raft; mast cell granule; plasma membrane; extracellular exosome; membrane; intracellular anatomical structure;
Biological process	B cell receptor signaling pathway; Fc-epsilon receptor signaling pathway; B cell activation; immune response-regulating signaling pathway; intracellular signal transduction; mast cell degranulation; adaptive immune response; calcium-mediated signaling; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	7462
	56743
	ENSG00000086730
	ENSMUSG00000040751
	Q9GZY6
	Q9JHL0
	NM_014146; NM_032463; NM_032464
	NM_020044; NM_022964
	NP_054865; NP_115852; NP_115853
	NP_064428; NP_075253
	Wikidata
View/Edit Human	View/Edit Mouse

Linker for activation of T-cells family member 2 is a protein that in humans is encoded by the LAT2 gene.

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.