KRT81

KRT81
Identifiers
Aliases	KRT81, HB1, Hb-1, KRTHB1, MLN137, ghHkb1, hHAKB2-1, keratin 81, K81
External IDs	OMIM: 602153; MGI: 1928858; HomoloGene: 55645; GeneCards: KRT81; OMA:KRT81 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,291,534 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,361,632 bp
RNA expression pattern
	Top expressed in
	testicle; ; hair follicle; ; placenta; ; mammary gland; ; olfactory zone of nasal mucosa; ; female breast; ; lactiferous gland; ; amniotic fluid; ; right coronary artery; ; bone;
	Top expressed in
	lip; ; right ventricle; ; tibiofemoral joint; ; hair follicle; ; granulocyte; ; skin of back; ; skin of abdomen; ; gastrula; ; motor neuron; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; structural molecule activity;
Cellular component	intermediate filament; keratin filament; extracellular space; cytosol;
Biological process	keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3887
	64818
	ENSG00000205426
	ENSMUSG00000067615
	Q14533
	Q9ERE2
	NM_002281
	NM_001166157
	NP_002272
	NP_001159629
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.