Importin subunit alpha-4

KPNA3
Identifiers
Aliases	KPNA3, IPOA4, SRP1, SRP1gamma, SRP4, hSRP1, karyopherin subunit alpha 3
External IDs	OMIM: 601892; MGI: 1100863; HomoloGene: 20520; GeneCards: KPNA3; OMA:KPNA3 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	49,792,682 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	61,677,323 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; deltoid muscle; ; tibialis anterior muscle; ; vastus lateralis muscle; ; glutes; ; secondary oocyte; ; triceps brachii muscle; ; thoracic diaphragm;
	Top expressed in
	extensor digitorum longus muscle; ; plantaris muscle; ; zygote; ; secondary oocyte; ; pineal gland; ; triceps brachii muscle; ; tail of embryo; ; vastus lateralis muscle; ; temporal muscle; ; triceps surae;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein C-terminus binding; protein binding; nuclear localization sequence binding; nuclear import signal receptor activity;
Cellular component	cytoplasm; cytosol; nuclear pore; nucleus; nucleoplasm; host cell;
Biological process	protein transport; viral entry into host cell; viral process; viral penetration into host nucleus; protein import into nucleus; NLS-bearing protein import into nucleus; modulation by virus of host cellular process; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	3839
	16648
	ENSG00000102753
	ENSMUSG00000021929
	O00505
	O35344
	NM_002267
	NM_008466
	NP_002258
	NP_032492
	Wikidata
View/Edit Human	View/Edit Mouse

Importin subunit alpha-4 also known as karyopherin subunit alpha-3 is a protein that in humans is encoded by the KPNA3 gene.

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60–100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA3, encodes a protein similar to certain nuclear transport proteins of Xenopus and human. The predicted amino acid sequence shows similarity to Xenopus importin, yeast SRP1, and human RCH1 (KPNA2), respectively. The similarities among these proteins suggests that karyopherin alpha-3 may be involved in the nuclear transport system.