KIF1C

KIF1C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2G1L
Identifiers
Aliases	KIF1C, LTXS1, SATX2, SAX2, SPAX2, SPG58, kinesin family member 1C
External IDs	OMIM: 603060; MGI: 1098260; HomoloGene: 4821; GeneCards: KIF1C; OMA:KIF1C - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	5,028,401 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,731,964 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; gastrocnemius muscle; ; muscle of thigh; ; apex of heart; ; left ventricle; ; right auricle of heart; ; Skeletal muscle tissue of rectus abdominis; ; Amygdala; ; olfactory bulb; ; Descending thoracic aorta;
	Top expressed in
	muscle of thigh; ; triceps brachii muscle; ; digastric muscle; ; vastus lateralis muscle; ; gastrocnemius muscle; ; myocardium of ventricle; ; sternocleidomastoid muscle; ; lip; ; ankle; ; ankle joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule binding; microtubule motor activity; nucleotide binding; ATPase activity; cytoskeletal motor activity; protein binding; ATP binding; RNA binding; plus-end-directed microtubule motor activity;
Cellular component	cytoplasm; Golgi apparatus; microtubule; cytoskeleton; endoplasmic reticulum; kinesin complex; axon; dendrite; neuron projection; axon cytoplasm;
Biological process	cytoskeleton-dependent intracellular transport; microtubule-based movement; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; vesicle-mediated transport; anterograde neuronal dense core vesicle transport; retrograde neuronal dense core vesicle transport;
	Sources:Amigo / QuickGO
Orthologs
	10749
	16562
	ENSG00000129250
	ENSMUSG00000020821
	O43896
	O35071
	NM_006612
	NM_153103
	NP_006603
	NP_694743
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-like protein KIF1C is a protein that in humans is encoded by the KIF1C gene. Kif1C is a fast, plus-end directed microtubule motor. It takes processive 8nm steps along microtubules and can generate forces of up to 5 pN. Kif1C transports α5β1-integrins in human cells. Kif1C has been shown to be non-essential in mouse with other proteins able to perform the same function. However, mutations in KIF1C lead to spastic paraplegia and cerebellar dysfunction in humans. These mutations usually result in a total loss of the protein or (partial) loss of function, such as significant lower force output.