KIF17

KIF17
Identifiers
Aliases	KIF17, Kif17, 5930435E01Rik, AW492270, Kif17b, mKIAA1405, KIF3X, KLP-2, OSM-3, kinesin family member 17
External IDs	OMIM: 605037; MGI: 1098229; HomoloGene: 5883; GeneCards: KIF17; OMA:KIF17 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	20,718,017 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,029,278 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; right adrenal cortex; ; left adrenal gland; ; spleen; ; left adrenal cortex; ; right frontal lobe; ; prefrontal cortex; ; testicle; ; apex of heart;
	Top expressed in
	primary oocyte; ; zygote; ; seminiferous tubule; ; secondary oocyte; ; spermatid; ; superior frontal gyrus; ; visual cortex; ; primary visual cortex; ; lumbar subsegment of spinal cord; ; dorsal striatum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; microtubule motor activity; microtubule binding; plus-end-directed microtubule motor activity; ATP binding; ATPase activity;
Cellular component	intraciliary transport particle B; cytoplasm; ciliary basal body; cytosol; kinesin complex; microtubule cytoskeleton; photoreceptor connecting cilium; periciliary membrane compartment; axoneme; microtubule; cytoskeleton; cell projection; cilium; dendrite cytoplasm; neuron projection;
Biological process	microtubule-based movement; cell projection organization; microtubule-based process; protein transport; protein-containing complex localization; vesicle-mediated transport; neurogenesis; intraciliary transport involved in cilium assembly; anterograde dendritic transport of neurotransmitter receptor complex;
	Sources:Amigo / QuickGO
Orthologs
	57576
	16559
	ENSG00000117245
	ENSMUSG00000028758
	Q9P2E2
	Q99PW8
	NM_001122819; NM_001287212; NM_020816
	NM_001190978; NM_010623
	NP_001116291; NP_001274141; NP_065867
	NP_001177907; NP_034753
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-like protein KIF17 is a protein that in humans is encoded by the KIF17 gene. KIF17 and its close relative, C. elegans OSM-3, are members of the kinesin-2 family of plus-end directed microtubule-based motor proteins. In contrast to heterotrimeric kinesin-2 motors, however, KIF17 and OSM-3 form distinct homodimeric complexes. Homodimeric kinesin-2 has been implicated in the transport of NMDA receptors along dendrites for delivery to the dendritic membrane, whereas both heterotrimeric and homodimeric kinesin-2 motors function cooperatively in anterograde intraflagellar transport (IFT) and cilium biogenesis.