KCNK6

KCNK6
Identifiers
Aliases	KCNK6, K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2, potassium two pore domain channel subfamily K member 6
External IDs	OMIM: 603939; MGI: 1891291; HomoloGene: 31266; GeneCards: KCNK6; OMA:KCNK6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	38,332,076 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,931,940 bp
RNA expression pattern
	Top expressed in
	decidua; ; ectocervix; ; monocyte; ; right coronary artery; ; ascending aorta; ; myometrium; ; mucosa of transverse colon; ; vagina; ; smooth muscle tissue; ; parotid gland;
	Top expressed in
	fossa; ; skin of abdomen; ; right lobe of liver; ; epithelium of stomach; ; Paneth cell; ; parotid gland; ; condyle; ; stroma of bone marrow; ; mesenteric lymph nodes; ; umbilical cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inward rectifier potassium channel activity; voltage-gated ion channel activity; potassium channel activity; potassium ion leak channel activity;
Cellular component	integral component of membrane; voltage-gated potassium channel complex; plasma membrane; membrane; integral component of plasma membrane;
Biological process	regulation of resting membrane potential; potassium ion transport; regulation of ion transmembrane transport; cardiac conduction; ion transport; negative regulation of systemic arterial blood pressure; potassium ion transmembrane transport; regulation of systemic arterial blood pressure; stabilization of membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	9424
	52150
	ENSG00000099337
	ENSMUSG00000046410
	Q9Y257
	n/a
	NM_004823
	NM_001033525
	NP_004814; NP_004814.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 6 is a protein encoded by the KCNK6 gene in humans.

This gene encodes K_2P6.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid and inhibited by internal acidification and volatile anaesthetics.