KCND3

KCND3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1S1G, 2NZ0
Identifiers
Aliases	KCND3, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22, BRGDA9, potassium voltage-gated channel subfamily D member 3
External IDs	OMIM: 605411; MGI: 1928743; HomoloGene: 21036; GeneCards: KCND3; OMA:KCND3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	111,989,668 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	105,581,318 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; pars reticulata; ; lateral nuclear group of thalamus; ; pars compacta; ; paraflocculus of cerebellum; ; Brodmann area 23; ; middle temporal gyrus; ; tail of epididymis; ; parietal lobe; ; caput epididymis;
	Top expressed in
	substantia nigra; ; ventral tegmental area; ; lateral geniculate nucleus; ; medial geniculate nucleus; ; habenula; ; vas deferens; ; anterior amygdaloid area; ; subiculum; ; pineal gland; ; supraoptic nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	potassium channel activity; transmembrane transporter binding; metal ion binding; voltage-gated ion channel activity; ion channel activity; protein binding; voltage-gated potassium channel activity; A-type (transient outward) potassium channel activity; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;
Cellular component	integral component of membrane; cell projection; membrane; voltage-gated potassium channel complex; plasma membrane; dendrite; sarcolemma; GABA-ergic synapse; integral component of postsynaptic specialization membrane; soma;
Biological process	regulation of ion transmembrane transport; ion transport; potassium ion transport; membrane repolarization; transmembrane transport; potassium ion transmembrane transport; protein homooligomerization; membrane repolarization during cardiac muscle cell action potential; regulation of heart rate by cardiac conduction; potassium ion export across plasma membrane; membrane repolarization during ventricular cardiac muscle cell action potential; ventricular cardiac muscle cell membrane repolarization; cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	3752
	56543
	ENSG00000171385
	ENSMUSG00000040896
	Q9UK17
	Q9Z0V1
	NM_004980; NM_172198; NM_001378969; NM_001378970
	NM_001039347; NM_019931
	NP_004971; NP_751948; NP_001365898; NP_001365899
	NP_001034436; NP_064315
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily D member 3 also known as K_v4.3 is a protein that in humans is encoded by the KCND3 gene. It contributes to the cardiac transient outward potassium current (I_to1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.