JHW-007

JHW-007
Identifiers
	IUPAC name (1R,5S)-3-[bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octane;
CAS Number	264869-07-0;
PubChem CID	10091491;
ChemSpider	1125316;
ChEMBL	ChEMBL3084652;
Chemical and physical data
Formula	C24H29F2NO
Molar mass	385.499 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCN1[C@@H]2CC[C@H]1CC(C2)OC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F;
	InChI InChI=1S/C24H29F2NO/c1-2-3-14-27-21-12-13-22(27)16-23(15-21)28-24(17-4-8-19(25)9-5-17)18-6-10-20(26)11-7-18/h4-11,21-24H,2-3,12-16H2,1H3/t21-,22+,23?; Key:HZEVDVGPBUFIAW-AIZNXBIQSA-N;

JHW-007 is a cocaine analogue and a high affinity atypical dopamine reuptake inhibitor that is being researched for the treatment of cocaine addiction. JHW-007 has been found to blunt the psychostimulant effects of cocaine and reduce self-administration in rodents. JHW-007 exposure has been shown to block the conditioned place preference effects of cocaine. JHW-007 may directly antagonize the autoregulatory dopamine D₂ receptor, a hypothesis that was developed following the observation of JHW-007's ability to inhibit D₂ receptor-mediated currents in the midbrain.

Identifiers

IUPAC name (1R,5S)-3-[bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octane
CAS Number	264869-07-0
PubChem CID	10091491
ChemSpider	1125316
ChEMBL	ChEMBL3084652
Chemical and physical data
Formula	C₂₄H₂₉F₂NO
Molar mass	385.499 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCCCN1[C@@H]2CC[C@H]1CC(C2)OC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
InChI InChI=1S/C24H29F2NO/c1-2-3-14-27-21-12-13-22(27)16-23(15-21)28-24(17-4-8-19(25)9-5-17)18-6-10-20(26)11-7-18/h4-11,21-24H,2-3,12-16H2,1H3/t21-,22+,23? Key:HZEVDVGPBUFIAW-AIZNXBIQSA-N