IQSEC1

IQSEC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3QWM, 4C0A
Identifiers
Aliases	IQSEC1, ARF-GEP100, ARFGEP100, BRAG2, GEP100, IQ motif and Sec7 domain 1, IQ motif and Sec7 domain ArfGEF 1, IDDSSBA
External IDs	OMIM: 610166; MGI: 1196356; HomoloGene: 82429; GeneCards: IQSEC1; OMA:IQSEC1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	13,283,281 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	90,965,667 bp
RNA expression pattern
	Top expressed in
	Brodmann area 46; ; postcentral gyrus; ; superior frontal gyrus; ; right frontal lobe; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 9; ; middle temporal gyrus; ; primary visual cortex;
	Top expressed in
	granulocyte; ; primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; cerebellar cortex; ; yolk sac; ; pontine nuclei; ; deep cerebellar nuclei; ; central gray substance of midbrain;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; lipid binding; protein binding;
Cellular component	cytoplasm; membrane; nucleus; nucleolus; intracellular membrane-bounded organelle;
Biological process	positive regulation of GTPase activity; regulation of ARF protein signal transduction; actin cytoskeleton organization; positive regulation of keratinocyte migration; positive regulation of adherens junction organization;
	Sources:Amigo / QuickGO
Orthologs
	9922
	232227
	ENSG00000144711
	ENSMUSG00000034312
	Q6DN90
	Q8R0S2
	NM_001134382; NM_014869; NM_001330619; NM_001376938
	NM_001134383; NM_001134384; NM_182784; NM_001356440
	NP_001127854; NP_001317548; NP_055684; NP_001363867
	NP_001127855; NP_001127856; NP_001343369
	Wikidata
View/Edit Human	View/Edit Mouse

IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP₁₀₀ (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.