INTS6

INTS6
Identifiers
Aliases	INTS6, DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2, integrator complex subunit 6
External IDs	OMIM: 604331; MGI: 1202397; HomoloGene: 8121; GeneCards: INTS6; OMA:INTS6 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	51,454,264 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	62,998,618 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Achilles tendon; ; optic nerve; ; right testis; ; left testis; ; epithelium of colon; ; tonsil; ; body of pancreas; ; ventricular zone; ; gingival epithelium;
	Top expressed in
	spermatocyte; ; spermatid; ; tail of embryo; ; seminiferous tubule; ; Gonadal ridge; ; lacrimal gland; ; genital tubercle; ; human fetus; ; gastrula; ; cumulus cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; transmembrane signaling receptor activity;
Cellular component	integrator complex; actin cytoskeleton; nucleoplasm; nucleus;
Biological process	snRNA processing; snRNA transcription by RNA polymerase II; signal transduction; snRNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologs
	26512
	18130
	ENSG00000102786
	ENSMUSG00000035161
	Q9UL03
	Q6PCM2
	NM_001039937; NM_001039938; NM_001306091; NM_012141
	NM_008715
	NP_001035026; NP_001035027; NP_001293020; NP_036273
	NP_032741
	Wikidata
View/Edit Human	View/Edit Mouse

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.