ILKAP

ILKAP
Identifiers
Aliases	ILKAP, ILKAP2, ILKAP3, PP2C-DELTA, PPM1O, ILK associated serine/threonine phosphatase, PP2CD
External IDs	MGI: 1914694; HomoloGene: 31525; GeneCards: ILKAP; OMA:ILKAP - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	238,203,708 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	91,398,815 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; granulocyte; ; gastric mucosa; ; muscle layer of sigmoid colon; ; anterior pituitary; ; body of uterus; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; tibial nerve;
	Top expressed in
	neural layer of retina; ; ventricular zone; ; neural tube; ; granulocyte; ; epiblast; ; thymus; ; muscle of thigh; ; right kidney; ; lip; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine phosphatase activity; protein binding; catalytic activity; phosphoprotein phosphatase activity; hydrolase activity; metal ion binding; cation binding;
Cellular component	cytoplasm; nucleus; nucleoplasm; cytosol;
Biological process	protein dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	80895
	67444
	ENSG00000132323
	ENSMUSG00000026309
	Q9H0C8
	Q8R0F6
	NM_030768; NM_176799
	NM_023343; NM_001355152
	NP_110395
	NP_075832; NP_001342081
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.