IHCH-7086

IHCH-7086
Identifiers
	IUPAC name (6bR,10aS)-2,3,6b,7,8,9,10,10a-octahydro-8-[3-(2-methoxyphenyl)propyl]-3-methyl-1H-Pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline;
CAS Number	2957888-70-7 ;
PubChem CID	162421364;
Chemical and physical data
Formula	C24H31N3O
Molar mass	377.532 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(CCN1[C@]2([H])[C@@]3([H])CN(CCCC4=CC=CC=C4OC)CC2)C5=C1C3=CC=C5;
	InChI InChI=InChI=1S/C24H31N3O/c1-25-15-16-27-21-12-14-26(13-6-8-18-7-3-4-11-23(18)28-2)17-20(21)19-9-5-10-22(25)24(19)27/h3-5,7,9-11,20-21H,6,8,12-17H2,1-2H3/t20-,21-/m0/s1; Key:WFYFRJAKNJVZMP-SFTDATJTSA-N;

IHCH-7086 is a drug which acts as an agonist at the 5-HT_2A serotonin receptor. It was derived by structural simplification of the 5-HT_2A antagonist atypical antipsychotic drug lumateperone along with several related compounds such as IHCH-7079, which was found to be a non-hallucinogenic biased 5-HT_2A agonist that was active in antidepressant assays but did not produce psychedelic-like responding in mice. The related structure IHCH-7113 was found to produce a positive head-twitch response in mice, suggesting likely hallucinogenic activity in humans.

Identifiers

IUPAC name (6bR,10aS)-2,3,6b,7,8,9,10,10a-octahydro-8-[3-(2-methoxyphenyl)propyl]-3-methyl-1H-Pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline
CAS Number	2957888-70-7^Y
PubChem CID	162421364
Chemical and physical data
Formula	C₂₄H₃₁N₃O
Molar mass	377.532 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN(CCN1[C@]2([H])[C@@]3([H])CN(CCCC4=CC=CC=C4OC)CC2)C5=C1C3=CC=C5
InChI InChI=InChI=1S/C24H31N3O/c1-25-15-16-27-21-12-14-26(13-6-8-18-7-3-4-11-23(18)28-2)17-20(21)19-9-5-10-22(25)24(19)27/h3-5,7,9-11,20-21H,6,8,12-17H2,1-2H3/t20-,21-/m0/s1 Key:WFYFRJAKNJVZMP-SFTDATJTSA-N