IFIT3

IFIT3
Identifiers
Aliases	IFIT3, CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G, cig41, interferon induced protein with tetratricopeptide repeats 3
External IDs	OMIM: 604650; MGI: 1101055; HomoloGene: 1189; GeneCards: IFIT3; OMA:IFIT3 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	89,377,473 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	34,566,131 bp
RNA expression pattern
	Top expressed in
	trigeminal ganglion; ; jejunal mucosa; ; pericardium; ; lower lobe of lung; ; spinal ganglia; ; human penis; ; palpebral conjunctiva; ; monocyte; ; endothelial cell; ; synovial joint;
	Top expressed in
	right kidney; ; granulocyte; ; human kidney; ; thymus; ; jejunum; ; lung; ; colon; ; adrenal gland; ; spleen; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	identical protein binding; protein binding; molecular function; RNA binding;
Cellular component	cytoplasm; mitochondrion; cytosol;
Biological process	immune system process; response to virus; innate immune response; negative regulation of apoptotic process; defense response to virus; type I interferon signaling pathway; negative regulation of cell population proliferation; cellular response to interferon-alpha; response to bacterium; cellular response to interferon-beta;
	Sources:Amigo / QuickGO
Orthologs
	3437
	15959
	ENSG00000119917
	ENSMUSG00000074896
	O14879
	Q64345
	NM_001549; NM_001031683; NM_001289758; NM_001289759
	NM_010501
	NP_001026853; NP_001276687; NP_001276688; NP_001540
	NP_034631
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-induced protein with tetratricopeptide repeats 3, also known as interferon-stimulated gene 49 (ISG49), is a protein that in humans is encoded by the IFIT3 gene. It plays a part in the innate immune response to viruses in response to type I interferon signaling.