IER3

IER3
Identifiers
Aliases	IER3, DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1, immediate early response 3
External IDs	OMIM: 602996; MGI: 104814; HomoloGene: 2894; GeneCards: IER3; OMA:IER3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,744,548 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	36,133,815 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; islet of Langerhans; ; gastric mucosa; ; gallbladder; ; body of stomach; ; granulocyte; ; bone marrow; ; left uterine tube; ; vagina; ; right auricle of heart;
	Top expressed in
	right lung lobe; ; granulocyte; ; decidua; ; stroma of bone marrow; ; cervix; ; motor neuron; ; endothelial cell of lymphatic vessel; ; left lung; ; corneal stroma; ; superior surface of tongue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; membrane; nucleus; cytosol;
Biological process	anatomical structure morphogenesis; regulation of response to DNA damage stimulus; negative regulation of apoptotic process; apoptotic process; regulation of phosphatidylinositol 3-kinase signaling; regulation of cell death;
	Sources:Amigo / QuickGO
Orthologs
	8870
	15937
	ENSG00000137331
	ENSMUSG00000003541
	P46695
	P46694; Q91VZ5
	NM_052815; NM_003897
	NM_133662
	NP_003888
	NP_598423
	Wikidata
View/Edit Human	View/Edit Mouse

Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3 gene.

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.