ICMT

ICMT
Identifiers
Aliases	ICMT, HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT, isoprenylcysteine carboxyl methyltransferase, ICMT protein, human
External IDs	OMIM: 605851; MGI: 1888594; HomoloGene: 5735; GeneCards: ICMT; OMA:ICMT - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	6,235,972 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	152,307,121 bp
RNA expression pattern
	Top expressed in
	thoracic diaphragm; ; stromal cell of endometrium; ; body of tongue; ; olfactory zone of nasal mucosa; ; gastrocnemius muscle; ; islet of Langerhans; ; nasal epithelium; ; right ventricle; ; glutes; ; muscle of thigh;
	Top expressed in
	neural layer of retina; ; lobe of cerebellum; ; cerebellar vermis; ; spermatocyte; ; lumbar spinal ganglion; ; spermatid; ; retinal pigment epithelium; ; lip; ; dentate gyrus of hippocampal formation granule cell; ; right kidney;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; protein C-terminal carboxyl O-methyltransferase activity; protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	post-translational protein modification; methylation; protein targeting to membrane; C-terminal protein methylation;
	Sources:Amigo / QuickGO
Orthologs
	23463
	57295
	ENSG00000116237
	ENSMUSG00000039662
	O60725
	Q9EQK7
	NM_012405; NM_170705
	NM_133788
	NP_036537
	NP_598549
	Wikidata
View/Edit Human	View/Edit Mouse

Protein-S-isoprenylcysteine O-methyltransferase is an enzyme that in humans is encoded by the ICMT gene.

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.