Hyperforin
| Clinical data | |
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| Dependence liability | None |
| Routes of administration | Oral |
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| Pharmacokinetic data | |
| Metabolism | Hepatic and CYP3A & CYP2B |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.112.565 |
| Chemical and physical data | |
| Formula | C35H52O4 |
| Molar mass | 536.797 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 79–80 °C (174–176 °F) |
| Solubility in water | 0.66 mg/mL (20 °C) |
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| (what is this?) (verify) | |
Hyperforin is a phytochemical produced by some of the members of the plant genus Hypericum, notably Hypericum perforatum (St John's wort). Hyperforin may be involved in the pharmacological effects of St. John's wort, specifically in its antidepressant effects. Meta-analyses of clinical trials suggest that H. perforatum is as effective as SSRIs for treating mild to moderate depression and is better tolerated, although findings are limited by short study durations.
Hyperforin is found in significant amounts only in H. perforatum, where it accumulates as a probable plant defense compound, with modern CO₂ extraction methods used to isolate it from mixtures containing related compounds like adhyperforin.