Hemagglutinin-neuraminidase
| Hemagglutinin-neuraminidase, Paramyxoviridae | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Structure of the sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase. | |||||||||||
| Identifiers | |||||||||||
| Symbol | HN | ||||||||||
| Pfam | PF00423 | ||||||||||
| Pfam clan | CL0434 | ||||||||||
| InterPro | IPR000665 | ||||||||||
| SCOP2 | 1usr / SCOPe / SUPFAM | ||||||||||
| CAZy | GH83 | ||||||||||
| CDD | cd15469 | ||||||||||
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Hemagglutinin-neuraminidase refers to a single viral protein that has both hemagglutinin and (endo) neuraminidase EC 3.2.1.18 activity. This is in contrast to the proteins found in influenza, where both functions exist but in two separate proteins. Its neuraminidase domain has the CAZy designation glycoside hydrolase family 83 (GH83).
It does show a structural similarity to influenza viral neuraminidase and has a six-bladed beta-propeller structure. This Pfam entry also matches measles hemagglutinin (cd15467), which has a "dead" neuraminidase part repurposed as a receptor binding site.
Hemagglutinin-neuraminidase allows the virus to stick to a potential host cell, and cut itself loose if necessary. Hemagglutinin-neuraminidase can be found in a variety of paramyxoviruses including mumps virus, human parainfluenza virus 3, and the avian pathogen Newcastle disease virus.
Types include:
Hemagglutinin-neuraminidase inhibitors have been investigated and suggest that there may applications for human use in the future.