Serine protease HTRA1

HTRA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JOA, 2YTW, 3NUM, 3NWU, 3NZI, 3TJN, 3TJO, 3TJQ
Identifiers
Aliases	HTRA1, ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11, CADASIL2, HtrA serine peptidase 1
External IDs	OMIM: 602194; MGI: 1929076; HomoloGene: 31114; GeneCards: HTRA1; OMA:HTRA1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	122,514,907 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	130,587,390 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; glomerulus; ; metanephric glomerulus; ; Descending thoracic aorta; ; stromal cell of endometrium; ; ascending aorta; ; synovial membrane; ; middle frontal gyrus; ; synovial joint; ; putamen;
	Top expressed in
	decidua; ; epithelium of lens; ; facial motor nucleus; ; gastrula; ; cumulus cell; ; calvaria; ; umbilical cord; ; ascending aorta; ; motor neuron; ; tunica media of zone of aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	insulin-like growth factor binding; growth factor binding; peptidase activity; serine-type peptidase activity; hydrolase activity; serine-type endopeptidase activity; protein binding; identical protein binding;
Cellular component	cytoplasm; cytosol; membrane; extracellular matrix; plasma membrane; extracellular exosome; extracellular region; extracellular space; collagen-containing extracellular matrix;
Biological process	negative regulation of defense response to virus; chorionic trophoblast cell differentiation; positive regulation of epithelial cell proliferation; placenta development; dentinogenesis; negative regulation of transforming growth factor beta receptor signaling pathway; proteolysis; negative regulation of BMP signaling pathway; regulation of cell growth; extracellular matrix disassembly;
	Sources:Amigo / QuickGO
Orthologs
	5654
	56213
	ENSG00000166033
	ENSMUSG00000006205
	Q92743
	Q9R118
	NM_002775
	NM_019564
	NP_002766
	NP_062510
	Wikidata
View/Edit Human	View/Edit Mouse

Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene. The HTRA1 protein is composed of four distinct protein domains. They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a kazal domain, a trypsin-like peptidase domain and a PDZ domain.

This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.

Mutations of this gene are responsible for the development of CARASIL, a genetic form of cerebral vasculopathy.