HSF4

HSF4
Identifiers
Aliases	HSF4, CTM, CTRCT5, heat shock transcription factor 4
External IDs	OMIM: 602438; MGI: 1347058; HomoloGene: 100128; GeneCards: HSF4; OMA:HSF4 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,169,945 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,002,477 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; anterior pituitary; ; gastric mucosa; ; right uterine tube; ; body of pancreas; ; apex of heart; ; canal of the cervix; ; right ovary; ; left uterine tube; ; right frontal lobe;
	Top expressed in
	lens; ; muscle of thigh; ; female urethra; ; superior frontal gyrus; ; primary visual cortex; ; cerebellar cortex; ; central gray substance of midbrain; ; dentate gyrus of hippocampal formation granule cell; ; epithelium of lens; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; protein phosphatase binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleus; nuclear speck;
Biological process	eye development; regulation of transcription, DNA-templated; cell development; histone H3-K9 demethylation; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; protein homotrimerization; positive regulation of cell differentiation; positive regulation of cell population proliferation; camera-type eye development; negative regulation of transcription, DNA-templated; protein homooligomerization; positive regulation of transcription by RNA polymerase II; visual perception; cellular response to heat; positive regulation of transcription from RNA polymerase II promoter in response to heat stress;
	Sources:Amigo / QuickGO
Orthologs
	3299
	26386
	ENSG00000102878
	ENSMUSG00000033249
	Q9ULV5
	Q9R0L1
	NM_001538; NM_001040667; NM_001374674; NM_001374675
	NM_001256042; NM_001256044; NM_011939
	NP_001035757; NP_001529; NP_001361603; NP_001361604
	NP_001242971; NP_001242973; NP_036069
	Wikidata
View/Edit Human	View/Edit Mouse

Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene.

Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.