HSD17B1

HSD17B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A27, 1BHS, 1DHT, 1EQU, 1FDS, 1FDT, 1FDU, 1FDV, 1FDW, 1I5R, 1IOL, 1JTV, 1QYV, 1QYW, 1QYX, 3DEY, 3DHE, 3HB4, 3HB5, 3KLM, 3KLP, 3KM0
Identifiers
Aliases	HSD17B1, EDH17B2, EDHB17, HSD17, SDR28C1, hydroxysteroid (17-beta) dehydrogenase 1, hydroxysteroid 17-beta dehydrogenase 1, E2DH, 17-beta-HSD, 20-alpha-HSD, Hsd17b1
External IDs	OMIM: 109684; MGI: 105077; HomoloGene: 37303; GeneCards: HSD17B1; OMA:HSD17B1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,555,214 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,971,353 bp
RNA expression pattern
	Top expressed in
	placenta; ; gonad; ; left ovary; ; skin of abdomen; ; skin of leg; ; right ovary; ; muscle of thigh; ; stromal cell of endometrium; ; mucosa of transverse colon; ; left coronary artery;
	Top expressed in
	cumulus cell; ; Gonadal ridge; ; gastrula; ; morula; ; ovary; ; embryo; ; calvaria; ; blastocyst; ; granulocyte; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; catalytic activity; estradiol 17-beta-dehydrogenase activity; steroid binding; NADP+ binding; estradiol binding;
Cellular component	cytoplasm; cytosol;
Biological process	estrogen biosynthetic process; estrogen metabolic process; lipid metabolism; steroid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	3292
	15485
	ENSG00000108786
	ENSMUSG00000019301
	P14061
	P51656
	NM_000413; NM_001330219
	NM_010475
	NP_000404; NP_001317148
	NP_034605
	Wikidata
View/Edit Human	View/Edit Mouse

17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) is an enzyme that in humans is encoded by the HSD17B1 gene. This enzyme oxidizes or reduces the C17 hydroxy/keto group of androgens and estrogens and hence is able to regulate the potency of these sex steroids