Histidine-rich glycoprotein

HRG
Identifiers
Aliases	HRG, HPRG, HRGP, THPH11, histidine rich glycoprotein
External IDs	OMIM: 142640; MGI: 2146636; HomoloGene: 133557; GeneCards: HRG; OMA:HRG - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	186,678,234 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	22,780,406 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; kidney tubule; ; renal medulla; ; glomerulus; ; metanephric glomerulus; ; oocyte; ; secondary oocyte; ; human kidney; ; testicle;
	Top expressed in
	left lobe of liver; ; gallbladder; ; proximal tubule; ; right kidney; ; sexually immature organism; ; embryo; ; medial head of gastrocnemius muscle; ; human kidney; ; thoracic diaphragm; ; lens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	heparin binding; cysteine-type endopeptidase inhibitor activity; zinc ion binding; immunoglobulin binding; metal ion binding; protein binding; heme binding; serine-type endopeptidase inhibitor activity; heparan sulfate proteoglycan binding; signaling receptor binding;
Cellular component	endolysosome; blood microparticle; plasma membrane; extracellular region; extracellular exosome; platelet alpha granule lumen; cell surface; collagen-containing extracellular matrix;
Biological process	hemostasis; negative regulation of cell adhesion; negative regulation of fibrinolysis; regulation of actin cytoskeleton organization; negative regulation of blood vessel endothelial cell migration; positive regulation of immune response to tumor cell; fibrinolysis; platelet degranulation; heme transport; negative regulation of endothelial cell chemotaxis; chemotaxis; positive regulation of blood vessel remodeling; negative regulation of cell growth; angiogenesis; positive regulation of apoptotic process; regulation of gene expression; negative regulation of angiogenesis; positive regulation of focal adhesion assembly; negative regulation of vascular endothelial growth factor signaling pathway; regulation of platelet activation; regulation of blood coagulation; regulation of protein-containing complex assembly; negative regulation of cell adhesion mediated by integrin; negative regulation of cell population proliferation; negative regulation of lamellipodium assembly; regulation of peptidyl-tyrosine phosphorylation; blood coagulation; platelet activation; negative regulation of endopeptidase activity; antimicrobial humoral immune response mediated by antimicrobial peptide;
	Sources:Amigo / QuickGO
Orthologs
	3273
	94175
	ENSG00000113905
	ENSMUSG00000022877
	P04196
	Q9ESB3
	NM_000412
	NM_053176
	NP_000403
	NP_444406
	Wikidata
View/Edit Human	View/Edit Mouse

Histidine-rich glycoprotein (HRG) is a glycoprotein that in humans is encoded by the HRG gene. The HRG protein is produced in the liver, and it could also be synthesized by monocytes, macrophages, and megakaryocytes. It possesses a multi-domain structure, which makes it capable of binding to numerous ligands and modulating various biological processes including immunity, vascularization and coagulation.