Haptoglobin-related protein

HPR
Identifiers
Aliases	HPR, A-259H10.2, HP
External IDs	OMIM: 140210; MGI: 96211; HomoloGene: 122206; GeneCards: HPR; OMA:HPR - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	72,077,246 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	110,305,804 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; apex of heart; ; left ventricle; ; right ventricle; ; right auricle of heart; ; myocardium of left ventricle; ; testicle; ; putamen; ; caudate nucleus; ; tibial nerve;
	Top expressed in
	lacrimal gland; ; gallbladder; ; left lobe of liver; ; granulocyte; ; right lung lobe; ; stroma of bone marrow; ; white adipose tissue; ; subcutaneous adipose tissue; ; tunica adventitia of aorta; ; tibiofemoral joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	hemoglobin binding; serine-type endopeptidase activity;
Cellular component	spherical high-density lipoprotein particle; extracellular region; extracellular exosome; blood microparticle; extracellular space;
Biological process	receptor-mediated endocytosis; acute inflammatory response; proteolysis; response to organic substance; positive regulation of cell death;
	Sources:Amigo / QuickGO
Orthologs
	3250
	15439
	ENSG00000261701
	ENSMUSG00000031722
	P00739
	Q61646
	NM_020995; NM_001384360
	NM_017370; NM_001329965
	NP_066275
	NP_001316894; NP_059066
	Wikidata
View/Edit Human	View/Edit Mouse

Haptoglobin-related protein (Hpr) is a serum protein that binds to haemoglobin of red blood cells and is present only in primates. It acts as a molecule of innate immunity in association with apolipoprotein L1 (ApoL 1)-containing high-density lipoprotein (HDL) particles. In humans, together with related serum protein, haptoglobin, it acts as a cell-killing agent as part of the trypanolytic factor against the protozoan parasite Trypanosoma brucei thereby providing natural resistance to African sleeping sickness. It is produced from the gene HPR that is located on the long arm of chromosome 16 within the HP (for haptoglobin) gene cluster.