HOXB3

HOXB3
Identifiers
Aliases	HOXB3, HOX2, HOX2G, Hox-2.7, homeobox B3
External IDs	OMIM: 142966; MGI: 96184; HomoloGene: 1617; GeneCards: HOXB3; OMA:HOXB3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	48,604,912 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	96,238,756 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; corpus epididymis; ; caput epididymis; ; seminal vesicula; ; gastric mucosa; ; muscle layer of sigmoid colon; ; tail of epididymis; ; transverse colon; ; beta cell; ; endometrium;
	Top expressed in
	efferent ductule; ; migratory enteric neural crest cell; ; tail of embryo; ; vas deferens; ; medullary collecting duct; ; inferior ganglion of vagus nerve; ; hair follicle; ; abdominal wall; ; Paneth cell; ; thoracic vertebral column;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	embryonic skeletal system morphogenesis; multicellular organism development; glossopharyngeal nerve morphogenesis; definitive hemopoiesis; thyroid gland development; cartilage development; face development; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; regulation of neurogenesis; rhombomere development; angiogenesis; hematopoietic progenitor cell differentiation; transcription, DNA-templated; anterior/posterior pattern specification; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3213
	15410
	ENSG00000120093
	ENSMUSG00000048763
	P14651
	P09026
NM_002146; NM_001330322; NM_001330323; NM_001384747; NM_001384749;
	NM_001384750
	NM_001079869; NM_010458
	NP_001317251; NP_001317252; NP_002137
	NP_001073338; NP_034588
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).