HOMER2

HOMER2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1I7A
Identifiers
Aliases	HOMER2, ACPD, CPD, HOMER-2, VESL-2, DFNA68, homer scaffolding protein 2, homer scaffold protein 2
External IDs	OMIM: 604799; MGI: 1347354; HomoloGene: 3560; GeneCards: HOMER2; OMA:HOMER2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	82,986,153 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	81,357,275 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; olfactory zone of nasal mucosa; ; muscle of thigh; ; minor salivary glands; ; gastrocnemius muscle; ; islet of Langerhans; ; Skeletal muscle tissue of rectus abdominis; ; skin of leg; ; parotid gland; ; skin of abdomen;
	Top expressed in
	lacrimal gland; ; parotid gland; ; transitional epithelium of urinary bladder; ; lateral septal nucleus; ; substantia nigra; ; Region I of hippocampus proper; ; crypt of lieberkuhn of small intestine; ; epithelium of stomach; ; olfactory epithelium; ; trigeminal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein homodimerization activity; protein domain specific binding; synaptic receptor adaptor activity; actin binding; G protein-coupled glutamate receptor binding; glutamate receptor binding; protein heterodimerization activity;
Cellular component	cytoplasm; soma; postsynaptic membrane; dendrite; synapse; postsynaptic density; membrane; apical part of cell; stereocilium tip; cell projection; stereocilium; plasma membrane; cell junction; cytosol; glutamatergic synapse; neuron projection;
Biological process	G protein-coupled glutamate receptor signaling pathway; chemical homeostasis within a tissue; behavioral response to cocaine; regulation of G protein-coupled receptor signaling pathway; hearing; calcium-mediated signaling using intracellular calcium source; negative regulation of interleukin-2 production; negative regulation of calcineurin-NFAT signaling cascade; regulation of store-operated calcium entry; positive regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	9455
	26557
	ENSG00000103942
	ENSMUSG00000025813
	Q9NSB8
	Q9QWW1
	NM_004839; NM_199330; NM_199331; NM_199332
	NM_001164086; NM_001164087; NM_011983; NM_177029
	NP_004830; NP_955362
	NP_001157558; NP_001157559; NP_036113
	Wikidata
View/Edit Human	View/Edit Mouse

Homer protein homolog 2 is a protein that in humans is encoded by the HOMER2 gene.

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth. Four transcript variants encoding distinct isoforms have been identified for this gene.