HMGB2

HMGB2
Identifiers
Aliases	HMGB2, HMG2, high mobility group box 2
External IDs	OMIM: 163906; MGI: 96157; HomoloGene: 37582; GeneCards: HMGB2; OMA:HMGB2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	173,334,432 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	57,969,033 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; secondary oocyte; ; amniotic fluid; ; embryo; ; trabecular bone; ; ganglionic eminence; ; bone marrow; ; tibia; ; thymus; ; germinal epithelium;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ventricular zone; ; granulocyte; ; yolk sac; ; zygote; ; embryo; ; blastocyst; ; embryo; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein domain specific binding; DNA-binding transcription factor activity; transcription factor binding; non-sequence-specific DNA binding, bending; single-stranded DNA binding; damaged DNA binding; protein binding; four-way junction DNA binding; cis-regulatory region sequence-specific DNA binding; RAGE receptor binding; chemoattractant activity; double-stranded DNA binding; DNA binding, bending; supercoiled DNA binding; RNA binding; transcription coactivator activity;
Cellular component	cytoplasm; nucleoplasm; chromosome; extracellular region; nucleolus; perinuclear region of cytoplasm; condensed chromosome; nucleus; extracellular space; protein-containing complex;
Biological process	DNA geometric change; positive regulation of interferon-beta production; nucleosome assembly; DNA recombination; apoptotic DNA fragmentation; male gonad development; regulation of transcription, DNA-templated; positive regulation of endothelial cell proliferation; positive regulation of erythrocyte differentiation; inflammatory response to antigenic stimulus; immune system process; regulation of transcription by RNA polymerase II; response to steroid hormone; chromatin organization; negative regulation of gene expression; transcription, DNA-templated; positive regulation of transcription, DNA-templated; chemotaxis; response to lipopolysaccharide; positive regulation of gene expression; positive regulation of nuclease activity; defense response to Gram-negative bacterium; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; V(D)J recombination; spermatogenesis; positive regulation of innate immune response; cell chemotaxis; DNA ligation involved in DNA repair; spermatid nucleus differentiation; positive regulation of DNA binding; innate immune response; negative regulation of transcription, DNA-templated; cellular response to lipopolysaccharide; inflammatory response; positive regulation of megakaryocyte differentiation; regulation of neurogenesis; regulation of stem cell proliferation; DNA topological change; positive regulation of transcription by RNA polymerase II; defense response to Gram-positive bacterium; positive chemotaxis; chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologs
	3148
	97165
	ENSG00000164104
	ENSMUSG00000054717
	P26583
	P30681
	NM_002129; NM_001130688; NM_001130689
	NM_008252; NM_001363443; NM_001363444; NM_001363445
	NP_001124160; NP_001124161; NP_002120
	NP_032278; NP_001350372; NP_001350373; NP_001350374
	Wikidata
View/Edit Human	View/Edit Mouse

High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene.