HLA-A66

HLA-A66
(MHC Class I, A cell surface antigen)
HLA-A66
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*66--, β2-microglobulin
Older namesA10
Subtypes
Subtype
allele
Available structures
A66.1 *6601
A66.2 *6602
{{{cNick3}}} *66{{{cAllele3}}}
{{{cNick4}}} *66{{{cAllele4}}}
Rare alleles
Subtype
allele
Available structures
A66.3 *6603
{{{rnick2}}} *66{{{rallele2}}}
{{{rnick3}}} *66{{{rallele3}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A66 (A66) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α66 subset of HLA-A α-chains. For A66, the alpha "A" chain are encoded by the HLA-A*66 allele group and the β-chain are encoded by B2M locus. A66 and A*66 are almost synonymous in meaning. A66 is a split antigen of the broad antigen serotype A10. A66 is a sister serotype of A25, A26, A34, and A43.

Further information: History and naming of human leukocyte antigens

A66 is more common in Africa and Southwest Europe. A66 (A*6601) is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele..

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