HERC2

HERC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KEO, 3KCI, 4L1M
Identifiers
Aliases	HERC2, p528, D15F37S1, MRT38, SHEP1, jdf2, HECT and RLD domain containing E3 ubiquitin protein ligase 2, LOC107987422
External IDs	OMIM: 605837; MGI: 103234; HomoloGene: 3430; GeneCards: HERC2; OMA:HERC2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	28,322,179 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	55,881,548 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; right hemisphere of cerebellum; ; pituitary gland; ; corpus callosum; ; muscle layer of sigmoid colon; ; anterior pituitary; ; superior frontal gyrus; ; right frontal lobe; ; prefrontal cortex; ; primary visual cortex;
	Top expressed in
	secondary oocyte; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; zygote; ; medial dorsal nucleus; ; muscle of thigh; ; ventral tegmental area; ; cerebellar cortex; ; medial vestibular nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; zinc ion binding; metal ion binding; SUMO binding; ubiquitin-protein transferase activity; protein binding; ubiquitin protein ligase binding; transferase activity; ubiquitin protein ligase activity;
Cellular component	cytoplasm; membrane; nucleoplasm; mitochondrial inner membrane; centriole; cytoskeleton; nucleus;
Biological process	cellular response to DNA damage stimulus; protein ubiquitination; spermatogenesis; intracellular protein transport; double-strand break repair via nonhomologous end joining; DNA repair; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	8924
	15204
	ENSG00000128731; ENSG00000276802; ENSG00000277278
	ENSMUSG00000030451
	O95714
	Q4U2R1
	NM_004667
	NM_010418; NM_001360080
	NP_004658
	NP_034548; NP_001347009
	Wikidata
View/Edit Human	View/Edit Mouse

HERC2, or HECT and RLD domain containing E3 ubiquitin protein ligase 2, is a giant E3 ubiquitin protein ligase, implicated in DNA repair regulation, pigmentation and neurological disorders. It is encoded by a gene of the same name belonging to the HERC family, which typically encodes large protein products with C-terminal HECT domains and one or more RCC1-like (RLD) domains.