HARS2

HARS2
Identifiers
Aliases	HARS2, HARSL, HARSR, HO3, PRLTS2, histidyl-tRNA synthetase 2, mitochondrial, HisRS
External IDs	OMIM: 600783; MGI: 1918041; HomoloGene: 40819; GeneCards: HARS2; OMA:HARS2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	140,699,305 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	36,925,615 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; apex of heart; ; granulocyte; ; mucosa of transverse colon; ; right adrenal cortex; ; rectum; ; right uterine tube; ; body of uterus; ; right ovary;
	Top expressed in
	neural layer of retina; ; ventricular zone; ; spermatocyte; ; superior frontal gyrus; ; right kidney; ; primary visual cortex; ; granulocyte; ; thymus; ; proximal tubule; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; ligase activity; protein binding; ATP binding; protein homodimerization activity; histidine-tRNA ligase activity; RNA binding; identical protein binding;
Cellular component	cytoplasm; mitochondrial matrix; mitochondrion; cytosol;
Biological process	protein biosynthesis; histidyl-tRNA aminoacylation; mitochondrial translation; tRNA aminoacylation for protein translation;
	Sources:Amigo / QuickGO
Orthologs
	23438
	70791
	ENSG00000112855
	ENSMUSG00000019143
	P49590
	Q99KK9
	NM_001278731; NM_001278732; NM_012208; NM_001363535; NM_001363536
	NM_080636; NM_001305627; NM_001360921
	NP_001265660; NP_001265661; NP_036340; NP_001350464; NP_001350465
	NP_001292556; NP_542367; NP_001347850
	Wikidata
View/Edit Human	View/Edit Mouse

Probable histidyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the HARS2 gene.

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter.