HARS

HARS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X59, 2LW7, 4G84, 4G85, 4PHC, 4X5O
Identifiers
Aliases	HARS1, HRS, USH3B, CMT2W, histidyl-tRNA synthetase, HARS, histidyl-tRNA synthetase 1
External IDs	OMIM: 142810; MGI: 108087; HomoloGene: 1592; GeneCards: HARS1; OMA:HARS1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	140,691,537 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	36,916,258 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; right frontal lobe; ; anterior pituitary; ; pars compacta; ; pars reticulata; ; right hemisphere of cerebellum; ; Brodmann area 9; ; nucleus accumbens; ; putamen; ; caudate nucleus;
	Top expressed in
	ureter; ; cingulate gyrus; ; primitive streak; ; fetal liver hematopoietic progenitor cell; ; medial vestibular nucleus; ; medullary collecting duct; ; lateral hypothalamus; ; epiblast; ; medial dorsal nucleus; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; ligase activity; ATP binding; histidine-tRNA ligase activity; identical protein binding;
Cellular component	cytoplasm; mitochondrion; cytosol;
Biological process	tRNA aminoacylation for protein translation; protein biosynthesis; mitochondrial translation; histidyl-tRNA aminoacylation;
	Sources:Amigo / QuickGO
Orthologs
	3035
	15115
	ENSG00000170445
	ENSMUSG00000001380
	P12081
	Q61035
NM_002109; NM_001258040; NM_001258041; NM_001258042; NM_001289092;
	NM_001289093; NM_001289094
	NM_008214
NP_001244969; NP_001244970; NP_001244971; NP_001276021; NP_001276022;
	NP_001276023; NP_002100
	NP_032240
	Wikidata
View/Edit Human	View/Edit Mouse

Histidyl-tRNA synthetase (HARS) also known as histidine-tRNA ligase, is an enzyme which in humans is encoded by the HARS gene.