HIST1H2BA

H2BC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WKJ
Identifiers
Aliases	H2BC1, H2BFU, STBP, TSH2B, TSH2B.1, bA317E16.3, TH2B, histone cluster 1, H2ba, histone cluster 1 H2B family member a, hTSH2B, HIST1H2BA, H2B clustered histone 1
External IDs	OMIM: 609904; MGI: 2448375; HomoloGene: 69356; GeneCards: H2BC1; OMA:H2BC1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	25,727,345 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	24,118,139 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; left testis; ; right testis; ; sperm; ; kidney; ; human kidney; ; right lobe of liver; ; metanephros; ; respiratory system;
	Top expressed in
	spermatocyte; ; spermatid; ; secondary oocyte; ; primary oocyte; ; zygote; ; embryo; ; embryo; ; testicle; ; genital tubercle; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein heterodimerization activity; DNA binding; histone binding; molecular function;
Cellular component	nucleosome; extrinsic component of plasma membrane; nucleus; chromosome; nucleoplasm; DNA packaging complex;
Biological process	mononuclear cell migration; nucleosome assembly; positive regulation of binding; nucleosome disassembly; plasminogen activation; inflammatory response; chromatin organization; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	255626
	319177
	ENSG00000146047
	ENSMUSG00000050799
	Q96A08
	P70696
	NM_170610
	NM_175663
	NP_733759
	NP_783594
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H2B type 1-A is a protein that in humans is encoded by the HIST1H2BA gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.