GrpE
GrpE (Gro-P like protein E) is a bacterial nucleotide exchange factor that is important for regulation of protein folding machinery, as well as the heat shock response. It is a heat-inducible protein and during stress it prevents unfolded proteins from accumulating in the cytoplasm. Accumulation of unfolded proteins in the cytoplasm can lead to cell death.
| GrpE Protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Crystal structure of GrpE homodimer interacting with ATPase binding site of DnaK, resolved at 2.8 angstrom. | |||||||||
| Identifiers | |||||||||
| Symbol | GrpE | ||||||||
| Pfam | PF01025 | ||||||||
| InterPro | IPR000740 | ||||||||
| PROSITE | PS01071 | ||||||||
| SCOP2 | 1dkg / SCOPe / SUPFAM | ||||||||
| CDD | cd00446 | ||||||||
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