Grey's Anatomy season 21

*Grey's Anatomy*
Grey's Anatomy
Season 21
	Promotional poster
Showrunner	Meg Marinis
Starring	Ellen Pompeo; Chandra Wilson; James Pickens, Jr.; Kevin McKidd; Caterina Scorsone; Camilla Luddington; Jason George; Kim Raver; Jake Borelli; Chris Carmack; Anthony Hill; Alexis Floyd; Harry Shum Jr.; Adelaide Kane; Midori Francis; Niko Terho;
No. of episodes	18
Release
Original network	ABC
Original release	September 26, 2024 –; May 15, 2025
Season chronology

The twenty-first season of the American medical drama television series Grey's Anatomy was announced on April 2, 2024, and premiered in the United States on the American Broadcasting Company (ABC) on September 26, 2024.

Although announced as departing during the season, Jake Borelli and Midori Francis retain their series regular status. Both have been series regulars since the sixteenth and nineteenth seasons, respectively. Jason George was repromoted as series regular following the conclusion of Station 19.