Gran Premio 25 de Mayo
| Class | Group 1 |
|---|---|
| Inaugurated | 1936 |
| Race information | |
| Distance | 2400 meters |
| Surface | Turf |
| Track | Hipódromo de San Isidro |
| Qualification | Three-year-olds and up |
| Purse | $70,000,000 ARS (2025) 1st: $35,000,000 ARS |
The Gran Premio 25 de Mayo (previously Premio San Isidro, Gran Premio San Isidro, Gran Premio Internacional 25 de Mayo) is a Group 1 horse race run at Hipódromo de San Isidro, in Buenos Aires, Argentina.
Since 2012, the winner receives a “Win and You're In” berth into the Breeders' Cup Turf through the international Breeders' Cup Challenge.