Gewald reaction

Gewald reaction
Named after Karl Gewald
Reaction type Ring forming reaction
Identifiers
Organic Chemistry Portal gewald-reaction

The Gewald reaction (or the Gewald aminothiophene synthesis) is an organic reaction involving the condensation of a ketone (or aldehyde when R2 = H) with a α-cyanoester in the presence of elemental sulfur and base to give a poly-substituted 2-amino-thiophene.

The reaction is named after the German chemist Karl Gewald.

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