GSTK1

GSTK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YZX, 3RPN, 3RPP
Identifiers
Aliases	GSTK1, GST, GST 13-13, GST13, GST13-13, GSTK1-1, hglutathione S-transferase kappa 1
External IDs	OMIM: 602321; MGI: 1923513; HomoloGene: 41075; GeneCards: GSTK1; OMA:GSTK1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	143,270,854 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	42,227,381 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; apex of heart; ; mucosa of transverse colon; ; right lobe of liver; ; rectum; ; monocyte; ; right adrenal cortex; ; right uterine tube; ; left lobe of thyroid gland; ; right lobe of thyroid gland;
	Top expressed in
	left lobe of liver; ; epithelium of stomach; ; right ventricle; ; duodenum; ; mucous cell of stomach; ; adrenal gland; ; myocardium of ventricle; ; pyloric antrum; ; interventricular septum; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-disulfide reductase activity; transferase activity; glutathione peroxidase activity; glutathione transferase activity; signaling receptor binding; protein binding;
Cellular component	mitochondrial inner membrane; mitochondrial matrix; peroxisome; extracellular exosome; intracellular anatomical structure; membrane; mitochondrion; peroxisomal matrix; cytosol;
Biological process	epithelial cell differentiation; glutathione derivative biosynthetic process; cellular oxidant detoxification; glutathione metabolic process; protein targeting to peroxisome;
	Sources:Amigo / QuickGO
Orthologs
	373156
	76263
	ENSG00000197448
	ENSMUSG00000029864
	Q9Y2Q3
	Q9DCM2
	NM_015917; NM_001143679; NM_001143680; NM_001143681
	NM_029555
	NP_001137151; NP_001137152; NP_001137153; NP_057001
	NP_083831
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione S-transferase kappa 1 (GSTK1) is an enzyme that in humans is encoded by the GSTK1 gene which is located on chromosome seven. It belongs to the superfamily of enzymes known as glutathione S-transferase (GST), which are mainly known for cellular detoxification. The GSTK1 gene consists of eight exons and seven introns and although it is a member of the GST family, its structure has been found to be similar to bacterial HCCA (2-hydroxychromene-2-carboxylate) isomerases and bacterial disulphide-bond-forming DsbA oxidoreductase. This similarity has later allowed the enzyme GSTK1 to be renamed to DsbA-L. Research has also suggested that several variations of the GSTK1 gene can be responsible for metabolic diseases and certain types of cancer.