GRIK3

GRIK3
Identifiers
Aliases	GRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a, glutamate ionotropic receptor kainate type subunit 3
External IDs	OMIM: 138243; MGI: 95816; HomoloGene: 73901; GeneCards: GRIK3; OMA:GRIK3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	37,034,515 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	125,607,966 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; spinal ganglia; ; trigeminal ganglion; ; prefrontal cortex; ; primary visual cortex; ; endothelial cell; ; Hypothalamus; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe;
	Top expressed in
	median eminence; ; arcuate nucleus; ; lateral septal nucleus; ; Rostral migratory stream; ; lateral hypothalamus; ; ventromedial nucleus; ; mammillary body; ; anterior amygdaloid area; ; paraventricular nucleus of hypothalamus; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	kainate selective glutamate receptor activity; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; ion channel activity; extracellularly glutamate-gated ion channel activity; ligand-gated ion channel activity; ionotropic glutamate receptor activity; G protein-coupled receptor binding; glutamate receptor activity; signaling receptor activity; ligand-gated ion channel activity involved in regulation of presynaptic membrane potential; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; plasma membrane; synapse; integral component of plasma membrane; cell junction; dendrite cytoplasm; perikaryon; dendrite; terminal bouton; axon; kainate selective glutamate receptor complex; presynaptic membrane; glutamatergic synapse;
Biological process	G protein-coupled glutamate receptor signaling pathway; glutamate receptor signaling pathway; ion transport; ion transmembrane transport; negative regulation of synaptic transmission, glutamatergic; ionotropic glutamate receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; regulation of membrane potential; excitatory postsynaptic potential; synaptic transmission, glutamatergic; modulation of chemical synaptic transmission; regulation of presynaptic membrane potential; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2899
	14807
	ENSG00000163873
	ENSMUSG00000001985
	Q13003
	B1AS29
	NM_000831
	NM_001081097
	NP_000822
	NP_001074566
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate receptor, ionotropic kainate 3 is a protein that in humans is encoded by the GRIK3 gene.

This gene encodes a protein that belongs to the ligand-gated ionic channel family. It can coassemble with either GRIK4 or GRIK5 to form heteromeric receptors and acts as an excitatory neurotransmitter at many synapses in the central nervous system. RNA editing in the mRNA has been reported.