GRIK2

GRIK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3QXM, 5CMM
Identifiers
Aliases	GRIK2, EAA4, GLR6, GLUK6, GLUR6, GluK2, MRT6, glutamate ionotropic receptor kainate type subunit 2, NEDLAS
External IDs	OMIM: 138244; MGI: 95815; HomoloGene: 40717; GeneCards: GRIK2; OMA:GRIK2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	102,081,622 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	49,788,766 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; middle temporal gyrus; ; paraflocculus of cerebellum; ; Brodmann area 23; ; Brodmann area 10; ; orbitofrontal cortex; ; superior frontal gyrus; ; entorhinal cortex;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; nucleus accumbens; ; inner renal medulla; ; lumbar subsegment of spinal cord; ; ventricular zone; ; superior frontal gyrus; ; spermatid; ; dorsal striatum; ; cerebellar cortex; ; tongue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	glutamate receptor activity; PDZ domain binding; kainate selective glutamate receptor activity; protein homodimerization activity; ion channel activity; ionotropic glutamate receptor activity; identical protein binding; ligand-gated ion channel activity; extracellularly glutamate-gated ion channel activity; signaling receptor activity; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding; ligand-gated ion channel activity involved in regulation of presynaptic membrane potential; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; perikaryon; postsynaptic membrane; membrane; plasma membrane; synapse; integral component of plasma membrane; cell junction; terminal bouton; axon; dendrite; dendrite cytoplasm; ionotropic glutamate receptor complex; postsynaptic density; kainate selective glutamate receptor complex; presynaptic membrane; soma; hippocampal mossy fiber to CA3 synapse; glutamatergic synapse;
Biological process	neuron apoptotic process; glutamate receptor signaling pathway; modulation of chemical synaptic transmission; ion transport; receptor clustering; ion transmembrane transport; positive regulation of neuron apoptotic process; regulation of JNK cascade; ionotropic glutamate receptor signaling pathway; positive regulation of synaptic transmission; excitatory postsynaptic potential; negative regulation of synaptic transmission, glutamatergic; chemical synaptic transmission; behavioral fear response; cellular calcium ion homeostasis; intracellular protein transport; neuronal action potential; synaptic transmission, glutamatergic; regulation of membrane potential; negative regulation of neuron apoptotic process; regulation of long-term neuronal synaptic plasticity; regulation of short-term neuronal synaptic plasticity; inhibitory postsynaptic potential; regulation of presynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2898
	14806
	ENSG00000164418
	ENSMUSG00000056073
	Q13002
	P39087
	NM_001166247; NM_021956; NM_175768
	NM_001111268; NM_010349
	NP_001159719; NP_068775; NP_786944
	NP_001104738; NP_034479; NP_001345795
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate ionotropic receptor kainate type subunit 2, also known as ionotropic glutamate receptor 6 or GluR6, is a protein that in humans is encoded by the GRIK2 (or GLUR6) gene.