Glutathione peroxidase 4

GPX4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GS3, 2OBI
Identifiers
Aliases	GPX4, GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx, SMDS, glutathione peroxidase 4
External IDs	OMIM: 138322; MGI: 104767; HomoloGene: 134384; GeneCards: GPX4; OMA:GPX4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,106,791 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,892,273 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; adipose tissue; ; retinal pigment epithelium; ; abdominal fat; ; subcutaneous adipose tissue; ; olfactory zone of nasal mucosa; ; left adrenal cortex; ; pituitary gland; ; right adrenal cortex;
	Top expressed in
	spermatid; ; proximal tubule; ; spermatocyte; ; bone marrow; ; white adipose tissue; ; right kidney; ; layer of retina; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	phospholipid-hydroperoxide glutathione peroxidase activity; oxidoreductase activity; peroxidase activity; glutathione peroxidase activity; identical protein binding; protein binding; selenium binding;
Cellular component	cytosol; extracellular exosome; cytoplasm; nucleus; nucleoplasm; mitochondrion; nuclear envelope; protein-containing complex;
Biological process	response to oxidative stress; multicellular organism development; lipoxygenase pathway; phospholipid metabolic process; cellular oxidant detoxification; protein polymerization; chromatin organization; glutathione metabolic process; spermatogenesis; ageing; response to estradiol; long-chain fatty acid biosynthetic process; regulation of inflammatory response; negative regulation of ferroptosis;
	Sources:Amigo / QuickGO
Orthologs
	2879
	625249
	ENSG00000167468
	ENSMUSG00000075706
	P36969
	Q76LV0; O70325
	NM_002085; NM_001039847; NM_001039848; NM_001367832
	NM_001037741; NM_008162; NM_001367995
	NP_001034936; NP_001034937; NP_002076; NP_001354761
	NP_001032830.2; NP_001032830; NP_032188; NP_001354924
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione peroxidase 4, also known as GPX4, is an enzyme that in humans is encoded by the GPX4 gene. GPX4 is a phospholipid hydroperoxidase that protects cells against membrane lipid peroxidation.