GPR139

GPR139
Identifiers
Aliases	GPR139, GPRg1, PGR3, G protein-coupled receptor 139
External IDs	OMIM: 618448; MGI: 2685341; HomoloGene: 45860; GeneCards: GPR139; OMA:GPR139 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	20,073,890 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	118,783,826 bp
RNA expression pattern
	Top expressed in
	testicle; ; caudate nucleus; ; putamen; ; nucleus accumbens; ; Hypothalamus; ; bone marrow; ; substantia nigra; ; pituitary gland; ; C1 segment; ; muscle tissue;
	Top expressed in
	lumbar spinal ganglion; ; habenula; ; medial vestibular nucleus; ; deep cerebellar nuclei; ; mammillary body; ; dorsal tegmental nucleus; ; dorsomedial hypothalamic nucleus; ; lateral hypothalamus; ; central gray substance of midbrain; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein dimerization activity; signal transducer activity; neuropeptide receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	124274
	209776
	ENSG00000180269
	ENSMUSG00000066197
	Q6DWJ6
	Q80UC8
	NM_001002911; NM_001318483
	NM_001024138
	NP_001002911; NP_001305412
	NP_001019309
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 139 (GPC139) is a protein that in humans is encoded by the GPR139 gene. Research has shown that mice with loss of GCP139 experience schizophrenia-like symptomatology that is rescued with the dopamine receptor antagonist haloperidol and the μ-opioid receptor antagonist naltrexone.