GOT1

GOT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3II0, 3WZF
Identifiers
Aliases	GOT1, ASTQTL1, GIG18, cAspAT, cCAT, AST1, glutamic-oxaloacetic transaminase 1
External IDs	OMIM: 138180; MGI: 95791; HomoloGene: 1571; GeneCards: GOT1; OMA:GOT1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	99,430,624 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	43,513,044 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; myocardium of left ventricle; ; apex of heart; ; cardiac muscle tissue of right atrium; ; body of tongue; ; right auricle of heart; ; vastus lateralis muscle; ; muscle of thigh; ; Skeletal muscle tissue of rectus abdominis; ; prefrontal cortex;
	Top expressed in
	extraocular muscle; ; right ventricle; ; digastric muscle; ; myocardium of ventricle; ; medial vestibular nucleus; ; temporal muscle; ; sternocleidomastoid muscle; ; pontine nuclei; ; cardiac muscles; ; deep cerebellar nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; L-aspartate:2-oxoglutarate aminotransferase activity; L-cysteine:2-oxoglutarate aminotransferase activity; transaminase activity; catalytic activity; carboxylic acid binding; L-phenylalanine:2-oxoglutarate aminotransferase activity; phosphatidylserine decarboxylase activity; pyridoxal phosphate binding;
Cellular component	cytoplasm; axon terminus; mitochondrion; lysosome; extracellular exosome; nucleus; nucleoplasm; cytosol;
Biological process	Notch signaling pathway; gluconeogenesis; dicarboxylic acid metabolic process; aspartate metabolic process; aspartate catabolic process; cellular amino acid metabolic process; response to glucocorticoid; cellular amino acid biosynthetic process; biosynthesis; 2-oxoglutarate metabolic process; oxaloacetate metabolic process; glutamate catabolic process to 2-oxoglutarate; aspartate biosynthetic process; fatty acid homeostasis; cellular response to insulin stimulus; glutamate catabolic process to aspartate; glutamate metabolic process; glycerol biosynthetic process; response to carbohydrate; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of collagen biosynthetic process; response to immobilization stress; response to cadmium ion; negative regulation of cytosolic calcium ion concentration; negative regulation of mitochondrial depolarization; transdifferentiation; cellular response to mechanical stimulus; response to transition metal nanoparticle;
	Sources:Amigo / QuickGO
Orthologs
	2805
	14718
	ENSG00000120053
	ENSMUSG00000025190
	P17174
	P05201
	NM_002079
	NM_010324
	NP_002070
	NP_034454
	Wikidata
View/Edit Human	View/Edit Mouse

Aspartate aminotransferase, cytoplasmic is an enzyme that in humans is encoded by the GOT1 gene.

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.