GNAO1

GNAO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3C7K
Identifiers
Aliases	GNAO1, EIEE17, G-ALPHA-o, GNAO, G protein subunit alpha o1, HLA-DQB1, NEDIM, DEE17, HG1G
External IDs	OMIM: 139311; MGI: 95775; HomoloGene: 39203; GeneCards: GNAO1; OMA:GNAO1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	56,357,444 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	94,696,016 bp
RNA expression pattern
	Top expressed in
	superficial temporal artery; ; entorhinal cortex; ; superior frontal gyrus; ; prefrontal cortex; ; right frontal lobe; ; putamen; ; postcentral gyrus; ; buccal mucosa cell; ; caudate nucleus; ; primary visual cortex;
	Top expressed in
	perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; habenula; ; cerebellar cortex; ; neural layer of retina; ; subiculum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; G-protein beta/gamma-subunit complex binding; signal transducer activity; metal ion binding; guanyl nucleotide binding; GTP binding; GTPase activity; signaling receptor binding; G protein-coupled serotonin receptor binding; mu-type opioid receptor binding; GTPase activating protein binding; protein-containing complex binding; corticotropin-releasing hormone receptor 1 binding; G protein-coupled receptor binding;
Cellular component	cell body; membrane; myelin sheath; plasma membrane; dendrite; heterotrimeric G-protein complex; neuron projection; protein-containing complex;
Biological process	G protein-coupled receptor signaling pathway; response to cytokine; muscle contraction; regulation of heart contraction; response to organic cyclic compound; locomotory behavior; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; ageing; dopamine receptor signaling pathway; response to morphine; positive regulation of GTPase activity; response to organonitrogen compound; negative regulation of calcium ion transport; forebrain development; neuron projection development; response to hydrogen peroxide; cellular process or phenomenon; signal transduction; protein folding; Wnt signaling pathway, calcium modulating pathway; odontogenesis of dentin-containing tooth;
	Sources:Amigo / QuickGO
Orthologs
	2775
	14681
	ENSG00000087258
	ENSMUSG00000031748
	P09471; Q8N6I9
	P18872
	NM_020988; NM_138736
	NM_001113384; NM_010308
	NP_066268; NP_620073; NP_066268.1; NP_620073.2
	NP_001106855; NP_034438
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene.

Mutations in this gene have been shown to cause epileptic encephalopathy.