GLRX5

GLRX5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MMZ, 2WUL
Identifiers
Aliases	GLRX5, C14orf87, FLB4739, GRX5, PR01238, PRO1238, PRSA, SIDBA3, SPAHGC, glutaredoxin 5
External IDs	OMIM: 609588; MGI: 1920296; HomoloGene: 31984; GeneCards: GLRX5; OMA:GLRX5 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	95,544,724 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	105,009,165 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; thoracic diaphragm; ; triceps brachii muscle; ; Skeletal muscle tissue of biceps brachii; ; vastus lateralis muscle; ; glutes; ; myocardium of left ventricle; ; endothelial cell; ; cardiac muscle tissue of right atrium; ; right ventricle;
	Top expressed in
	otolith organ; ; utricle; ; hand; ; human fetus; ; parotid gland; ; bone marrow; ; lacrimal gland; ; endothelial cell of lymphatic vessel; ; primitive streak; ; facial motor nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-disulfide reductase activity; electron transfer activity; iron-sulfur cluster binding; metal ion binding; 2 iron, 2 sulfur cluster binding; disulfide oxidoreductase activity; protein binding; glutathione disulfide oxidoreductase activity;
Cellular component	soma; dendrite; nucleus; mitochondrion; mitochondrial matrix;
Biological process	cell redox homeostasis; protein lipoylation; small molecule metabolic process; electron transport chain; hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
	51218
	73046
	ENSG00000182512
	ENSMUSG00000021102
	Q86SX6
	Q80Y14
	NM_016417
	NM_028419
	NP_057501
	NP_082695
	Wikidata
View/Edit Human	View/Edit Mouse

Glutaredoxin 5, also known as GLRX5, is a protein which in humans is encoded by the GLRX5 gene located on chromosome 14. This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron- sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia.