Gamma-glutamyl hydrolase

GGH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1L9X
Identifiers
Aliases	GGH, GH, gamma-glutamyl hydrolase, GATD10
External IDs	OMIM: 601509; MGI: 1329035; HomoloGene: 2881; GeneCards: GGH; OMA:GGH - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	63,039,407 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	20,066,750 bp
RNA expression pattern
	Top expressed in
	rectum; ; kidney tubule; ; ventricular zone; ; mucosa of sigmoid colon; ; mucosa of transverse colon; ; right lobe of liver; ; human penis; ; ganglionic eminence; ; gonad; ; glomerulus;
	Top expressed in
	parotid gland; ; lacrimal gland; ; left colon; ; submandibular gland; ; esophagus; ; Epithelium of choroid plexus; ; pyloric antrum; ; skin of external ear; ; pancreas; ; skin of abdomen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	exopeptidase activity; omega peptidase activity; hydrolase activity; gamma-glutamyl-peptidase activity;
Cellular component	melanosome; cytosol; lysosome; extracellular exosome; nucleus; extracellular region; extracellular space; azurophil granule lumen; specific granule lumen; tertiary granule lumen; vacuole;
Biological process	response to insulin; response to zinc ion; response to ethanol; proteolysis; neutrophil degranulation; tetrahydrofolylpolyglutamate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8836
	14590
	ENSG00000137563
	ENSMUSG00000073987
	Q92820
	Q9Z0L8
	NM_003878
	NM_010281
	NP_003869
	NP_034411
	Wikidata
View/Edit Human	View/Edit Mouse

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Gamma-glutamyl hydrolase
Gamma-glutamyl hydrolase
Identifiers
EC no.	3.4.19.9
CAS no.	9074-87-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

Gamma-glutamyl hydrolase is an enzyme that catalyses the following chemical reaction:

Hydrolysis of a gamma-glutamyl bond

This lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH.

In humans, gamma-glutamyl hydrolase is encoded by the GGH gene. This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.