GEM (gene)

GEM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CJW, 2G3Y, 2HT6
Identifiers
Aliases	GEM, KIR, GTP binding protein overexpressed in skeletal muscle
External IDs	OMIM: 600164; MGI: 99844; HomoloGene: 38024; GeneCards: GEM; OMA:GEM - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	94,262,350 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	11,714,752 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; gallbladder; ; tail of epididymis; ; vena cava; ; gastric mucosa; ; right coronary artery; ; ascending aorta; ; cartilage tissue; ; Descending thoracic aorta; ; mucosa of urinary bladder;
	Top expressed in
	ascending aorta; ; cumulus cell; ; aortic valve; ; skin of external ear; ; pineal gland; ; neural layer of retina; ; adrenal gland; ; endocardial cushion; ; spermatocyte; ; atrioventricular valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; magnesium ion binding; calmodulin binding; GDP binding; GTPase activity; calcium channel regulator activity;
Cellular component	spindle midzone; cytoplasmic side of plasma membrane; plasma membrane; midbody; mitotic spindle; nucleus; membrane;
Biological process	cell surface receptor signaling pathway; metaphase plate congression; chromosome organization; immune response; signal transduction; mitotic cell cycle; negative regulation of high voltage-gated calcium channel activity;
	Sources:Amigo / QuickGO
Orthologs
	2669
	14579
	ENSG00000164949
	ENSMUSG00000028214
	P55040
	P55041
	NM_181702; NM_005261
	NM_010276
	NP_005252; NP_859053
	NP_034406
	Wikidata
View/Edit Human	View/Edit Mouse

GTP-binding protein GEM is a protein that in humans is encoded by the GEM gene.

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.