Guanine deaminase

GDA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AQL, 3E0L, 2UZ9
Identifiers
Aliases	GDA, guanine deaminase, CYPIN, GUANASE, NEDASIN, Guanine deaminase, GAH
External IDs	OMIM: 139260; MGI: 95678; HomoloGene: 3171; GeneCards: GDA; OMA:GDA - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	72,257,193 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	21,450,809 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; jejunal mucosa; ; pancreatic ductal cell; ; endothelial cell; ; Brodmann area 46; ; Brodmann area 23; ; middle temporal gyrus; ; entorhinal cortex; ; superior frontal gyrus; ; parietal lobe;
	Top expressed in
	epithelium of small intestine; ; ventromedial nucleus; ; granulocyte; ; subiculum; ; olfactory tubercle; ; anterior amygdaloid area; ; conjunctival fornix; ; nucleus accumbens; ; piriform cortex; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; metal ion binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; zinc ion binding; guanine deaminase activity; protein binding;
Cellular component	cytosol; intracellular anatomical structure;
Biological process	guanine catabolic process; purine nucleotide catabolic process; nucleobase-containing compound metabolic process; nervous system development; guanine metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9615
	14544
	ENSG00000119125
	ENSMUSG00000058624
	Q9Y2T3
	Q9R111
NM_001242505; NM_001242506; NM_001242507; NM_004293; NM_001351571;
	NM_001351572; NM_001351573
	NM_010266
NP_001229434; NP_001229435; NP_001229436; NP_004284; NP_001338500;
	NP_001338501; NP_001338502
	NP_034396
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine deaminase also known as cypin, guanase, guanine aminase, GAH, and guanine aminohydrolase is an aminohydrolase enzyme which converts guanine to xanthine. Cypin is a major cytosolic protein that interacts with PSD-95. It promotes localized microtubule assembly in neuronal dendrites.