GADD45GIP1

GADD45GIP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y, 3J9M
Identifiers
Aliases	GADD45GIP1, CKBBP2, CKbetaBP2, CRIF1, MRP-L59, PLINP, PLINP-1, PRG6, Plinp1, GADD45G interacting protein 1
External IDs	OMIM: 605162; MGI: 1914947; HomoloGene: 33474; GeneCards: GADD45GIP1; OMA:GADD45GIP1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,957,223 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,562,111 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; mucosa of transverse colon; ; left ventricle; ; gastrocnemius muscle; ; right auricle of heart; ; triceps brachii muscle; ; anterior cingulate cortex; ; olfactory zone of nasal mucosa; ; right adrenal gland;
	Top expressed in
	left lobe of liver; ; primary oocyte; ; digastric muscle; ; extraocular muscle; ; interventricular septum; ; right ventricle; ; temporal muscle; ; myocardium of ventricle; ; sternocleidomastoid muscle; ; adrenal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	mitochondrial matrix; mitochondrial ribosome; nucleus; mitochondrion; ribosome;
Biological process	cell cycle; mitochondrial translational elongation; mitochondrial translational termination; viral process;
	Sources:Amigo / QuickGO
Orthologs
	90480
	102060
	ENSG00000179271
	ENSMUSG00000033751
	Q8TAE8
	Q9CR59
	NM_052850
	NM_183358
	NP_443082
	NP_899202
	Wikidata
View/Edit Human	View/Edit Mouse

Growth arrest and DNA-damage-inducible proteins-interacting protein 1 is a protein that in humans is encoded by the GADD45GIP1 gene.

GADD45GIP1, also known as CRIF1 is newly identified de novo components in large subunit of mitoribosome. It is essential for the translation of mitochondrial oxidative phosphorylation (OXPHOS) polypeptides in mammalian mitochondria. CRIF1 interacts with low-sulfur (LSU) proteins, some of which surround the exit tunnel of the mitoribosome, and also interacts with nascent OXPHOS polypeptides and the mitochondrial-specific chaperone Tid1. The essential role of CRIF1 in mitochondrial synthesis and membrane integration of OXPHOS polypeptides was shown in brain-specific CRIF1-deficient mice, which exhibited profound OXPHOS failure and marked neurodegeneration.