GADD45G

GADD45G
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WAL, 3FFM
Identifiers
Aliases	GADD45G, CR6, DDIT2, GADD45gamma, GRP17, growth arrest and DNA damage inducible gamma
External IDs	OMIM: 604949; MGI: 1346325; HomoloGene: 21334; GeneCards: GADD45G; OMA:GADD45G - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	89,606,555 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	52,002,504 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; right auricle of heart; ; right lobe of liver; ; right adrenal cortex; ; left adrenal cortex; ; popliteal artery; ; tibial arteries; ; canal of the cervix; ; gastrocnemius muscle; ; muscle of thigh;
	Top expressed in
	ventricular zone; ; decidua; ; saccule; ; muscle of thigh; ; granulocyte; ; islet of Langerhans; ; gastrula; ; sternocleidomastoid muscle; ; endothelial cell of lymphatic vessel; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	nucleus; cytoplasm;
Biological process	positive regulation of JNK cascade; multicellular organism development; positive regulation of apoptotic process; response to stress; cell differentiation; positive regulation of p38MAPK cascade; apoptotic process; regulation of cell cycle; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	10912
	23882
	ENSG00000130222
	ENSMUSG00000021453
	O95257
	Q9Z111; Q9R0S0
	NM_006705
	NM_011817
	NP_006696
	NP_035947
	Wikidata
View/Edit Human	View/Edit Mouse

Growth arrest and DNA-damage-inducible protein GADD45 gamma is a protein that in humans is encoded by the GADD45G gene on chromosome 9. GADD45G is also known as CR6, DDIT2, GRP17, OIG37, and GADD45gamma. GADD45G is involved in several different processes, including sexual development, human-specific brain development, tumor suppression, and the cellular stress response. GADD45G interacts with several other proteins that are involved in DNA repair, cell cycle control, apoptosis, and senescence. Low expression of GADD45G has been associated with many types of cancer.