Fyn-related kinase

FRK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D8J, 2DLY
Identifiers
Aliases	FRK, GTK, PTK5, RAK, Fyn-related kinase, fyn related Src family tyrosine kinase
External IDs	OMIM: 606573; MGI: 103265; HomoloGene: 48065; GeneCards: FRK; OMA:FRK - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	116,060,891 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	34,487,274 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of sigmoid colon; ; epithelium of nasopharynx; ; mucosa of paranasal sinus; ; bronchial epithelial cell; ; buccal mucosa cell; ; palpebral conjunctiva; ; parotid gland; ; sperm; ; corpus epididymis;
	Top expressed in
	seminal vesicula; ; jejunum; ; duodenum; ; renal pelvis; ; conjunctival fornix; ; large intestine; ; colon; ; inner renal medulla; ; left colon; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein binding; signaling receptor binding; ATP binding; non-membrane spanning protein tyrosine kinase activity; protein tyrosine kinase activity;
Cellular component	extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; intracellular anatomical structure; extracellular exosome; extracellular region; nucleus; nucleoplasm; cytoplasm; azurophil granule lumen; specific granule lumen; cytosol;
Biological process	cell differentiation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of transcription by RNA polymerase II; protein phosphorylation; peptidyl-tyrosine autophosphorylation; innate immune response; negative regulation of cell population proliferation; neutrophil degranulation; cell migration;
	Sources:Amigo / QuickGO
Orthologs
	2444
	14302
	ENSG00000111816
	ENSMUSG00000019779
	P42685
	Q922K9
	NM_002031
	NM_001159544; NM_010237; NM_001358769
	NP_002022
	NP_001153016; NP_034367; NP_001345698
	Wikidata
View/Edit Human	View/Edit Mouse

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.