FOXO6

FOXO6
Identifiers
Aliases	FOXO6, forkhead box O6
External IDs	OMIM: 611457; MGI: 2676586; HomoloGene: 82395; GeneCards: FOXO6; OMA:FOXO6 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	41,383,590 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	120,144,546 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; pituitary gland; ; anterior pituitary; ; testicle; ; muscle of thigh; ; right ovary; ; left ovary; ; left lobe of thyroid gland; ; body of uterus; ; placenta;
	Top expressed in
	ganglionic eminence; ; Claustrum; ; ventricular zone; ; subdivision of hippocampus; ; quadriceps femoris muscle; ; nucleus accumbens; ; hippocampus proper; ; skeletal muscle tissue; ; cingulate gyrus; ; Region I of hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; sequence-specific DNA binding;
Cellular component	nucleus;
Biological process	transcription, DNA-templated; regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	100132074
	329934
	ENSG00000204060; ENSG00000281518
	ENSMUSG00000052135
	A0A1X9RU27
	Q70KY4
	NM_001291281
	NM_194060
	NP_001278210
	NP_918949
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box O6 is a protein that in humans is encoded by the FOXO6 gene.

FoxO6 is expressed in the liver, skeletal muscle, and the hippocampus of the brain. In the liver, FoxO6 normally promotes gluconeogenesis in the fasted state, but insulin blocks Fox06 after feeding. In a condition of insulin resistance, insulin fails to block FoxO6, resulting in continued gluconeogenesis even after feeding.